HBOT research suggests that it may be a valuable adjunctive therapy for mTBI, PTSD, Cerebral Palsy, Multiple Sclerosis, Lyme Disease and other neurological conditions.  HBOT has been found to improve the cerebral metabolic rate, reduce cerebral edema, improve cerebral blood flow and reduce cerebral spinal fluid lactic acid levels.

Based on current thinking about the biology of Cerebral Palsy and Multiple Sclerosis, HBOT may be a valuable adjunct to conventional therapy.

In the case of Lyme Disease, it has been demonstrated the bacteria responsible for Lyme Disease, Borrelia burgdoferi, can survive in oxygen at sea level, but cannot live in an environment of high pressure oxygen. It is also known that this particular bacteria can become sequestered in cells and the cells may protect it from antibiotics, resulting in chronic Lyme Disease and persistent neurologic symptoms. In a study of 90 patients diagnosed with Lyme Disease unresponsive to antibiotics, the use of HBOT resulted in a significant decrease or elimination of symptoms and improved quality of life for 85% of patients.

• Cerebral Oxygenation And The Recoverable Brain (pdf)
• Hyperbaric Oxygen Therapy Promotes neurogenesis: where do we stand?

• Multicenter observational study of hyperbaric oxygen for mild traumatic brain injury with post-concussive symptoms (NBIRR)
• Low Pressure Hyperbaric Oxygen Therapy andSPECT Brain Imaging In the Treatment of Blast-Induced Chronic Traumatic Brain Injury (Post-Concussion Syndrome) and Post Traumatic Stress Disorder: A Case Report
• A Phase I Study Of Low-Pressure Hyperbaric Oxygen Therapy For Blast-Induced Post-Concussion Syndrome And Post-Traumatic Stress Disorder(pdf)
• Hyperbaric Oxygen Therapy Can Improve Post-Concussion Syndrome Years afterMild Traumatic Brain Injury – Randomized Prospective Trial
• RESEARCH PAPER: Improving Neuropsychological Function after Chronic Brain Injury With Hyperbaric Oxygen(pdf)
• A Prospective, Randomized Phase II Clinical Trial to Evaluate the Effect Of Combined Hyperbaric and Normobaric Hyperoxia on Cerebral Metabolism, Intracranial Pressure, Oxygen Toxicity, and Clinical Outcome in Severe Traumatic Brain Injury(pdf)

• Newhope Hyperbaric Oxygen Therapy Is Proving To Be Able To Take Children Significantly Beyond The Limits Of The Improvements That Were Previously Thought Possible(pdf)
• High Dose Oxygen Therapy for Cerebral Palsy and the Brain Injured Child (Documentation via SPECT Imaging)
• Neubauer; Hyperbaric oxygenation in cerebral palsy and the brain injured child(pdf)

• Hyperbaric-Oxygen Treatment ofMultiple Sclerosis — A Randomized, Placebo-Controlled, Double-Blind Study
• Multiple Sclerosis – Its Etiology, Pathogenesis And Therapeutics With Emphasis On The Controversial Use Of HBO (pdf)
• Patient Video Testimonial

• Hyperbaric Oxygenation In The Acute Stroke
• Hyperbaric Oxygen Induces Late Neuroplasticity in Post Stroke Patients – Randomized, Prospective Trial
• Hyperbaric Oxygen in the Treatment of Patients with Cerebral Stroke, Brain Trauma and Neurological Disease
• Reversal of Residual Stroke Symptoms Using Hyperbaric Oxygen Therapy
• Identification of hypometabolic areas in the brain using brain imaging and hyperbaric oxygen
• Hyperbaric Oxygen Therapy Promotes neurogenesis: where do we stand?

• Treatment of Lyme disease With Hyperbaric Oxygen Therapy

• Revisiting the expanded use of hyperbaric oxygen therapy for treatment of resistant migraines
• Normobaric and hyperbaric oxygen therapy for migraine and cluster headache
• Hyperbaric oxygen in the treatment of migraine with aura
• Practice parameter: Evidence-based guidelines for migraine headache (an evidence-based review)
• A preliminary report on hyperbaric oxygen in the relief of migraine headache

• Hyperbaric Oxygen Therapy and Alzheimer’s Disease
• Hyperbaric Oxygen Therapy Promotes neurogenesis: where do we stand?
• HBOT Showed Improvement in Alzheimer’s Disease
• Hyperbaric Oxygen Therapy for Altzheimer’s Dimentia with Positron Emission Tomography Imaging: A Case Report

• Hyperbaric Oxygen Treatment on a Parkinson’s Disease Patient; A case study
• Hyperbaric Oxygen Therapy Promotes neurogenesis: where do we stand?
• One-Two Punch: Glutathione and HBOT

• Subacute normobaric oxygen and hyperbaric oxygen therapy in drowning, reversal of brain volume loss; a case report
• Cerebral Oxygenation And The Recoverable Brain (pdf)
• Hyperbaric Oxygen in the Treatment of Patients with Cerebral Stroke, Brain Trauma and Neurological Disease